Scholarly & Creative Works
selected scholarly works & creative activities
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Article
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2023Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling. EXPERIMENTAL NEUROLOGY. 366.Full Text via DOI: 10.1016/j.expneurol.2023.114435 Web of Science: 001000162800001
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2023Chemogenetic manipulation of CX3CR1+ cells transiently induces hypolocomotion independent of microglia. MOLECULAR PSYCHIATRY. 28:2857-2871.Full Text via DOI: 10.1038/s41380-023-02128-6
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2023Voltage-Gated Proton Channel Hv1 Regulates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson's Disease ModelsFull Text via DOI: 10.3390/antiox12030582 Web of Science: 000957178800001
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2022Distinct effects of form selective cytochrome P450 inhibitors on cytochrome P450-mediated monooxygenase and hydrogen peroxide generating NADPH oxidase. TOXICOLOGY AND APPLIED PHARMACOLOGY. 455.Full Text via DOI: 10.1016/j.taap.2022.116258 Web of Science: 000875644700003
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2022IND01-03 Expert panel review of the neurotoxicology of Glyphosate in mammalian systems for risk assessment purposes. TOXICOLOGY LETTERS. 368:s80-s81.Full Text via DOI: 10.1016/j.toxlet.2022.07.234
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2022Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement MiceFull Text via DOI: 10.3390/ijms23179829 Web of Science: 000851083600001
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2022Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer's Disease Risk. ENVIRONMENTAL HEALTH PERSPECTIVES. 130.Full Text via DOI: 10.1289/EHP10576 Web of Science: 000898613000004
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2021Age, sex, and regional differences in scavenger receptor CD36 in the mouse brain: Potential relevance to cerebral amyloid angiopathy and Alzheimer's disease. JOURNAL OF COMPARATIVE NEUROLOGY. 529:2209-2226.Full Text via DOI: 10.1002/cne.25089 Web of Science: 000600676200001
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2021Analysis of six pyrethroid insecticide metabolites in cord serum using a novel gas chromatography-ion trap mass spectrometry method. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 1173.Full Text via DOI: 10.1016/j.jchromb.2021.122656 Web of Science: 000663325500022
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2020Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice. TOXICOLOGICAL SCIENCES. 178:347-357.Full Text via DOI: 10.1093/toxsci/kfaa144 Web of Science: 000608394200011
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2020Microglial depletion aggravates the severity of acute and chronic seizures in mice. BRAIN BEHAVIOR AND IMMUNITY. 89:245-255.Full Text via DOI: 10.1016/j.bbi.2020.06.028 Web of Science: 000582897600025
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2020Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration. MOLECULAR NEUROBIOLOGY. 57:2920-2933.Full Text via DOI: 10.1007/s12035-020-01921-6 Web of Science: 000534452200001
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2020Nerve Growth Factor Protects Against Pyrethroid-Induced Endoplasmic Reticulum (ER) Stress in Primary Hippocampal Neurons. TOXICOLOGICAL SCIENCES. 174:147-158.Full Text via DOI: 10.1093/toxsci/kfz239 Web of Science: 000535691100014
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2020Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration. FASEB JOURNAL. 34:1679-1694.Full Text via DOI: 10.1096/fj.201900567RR Web of Science: 000507308900111
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2019Epigenetic Regulation of the Ontogenic Expression of the Dopamine TransporterFull Text via DOI: 10.3389/fgene.2019.01099 Web of Science: 000497725800001
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2019Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling. MOLECULAR NEUROBIOLOGY. 56:6986-7002.Full Text via DOI: 10.1007/s12035-019-1565-7 Web of Science: 000486010800023
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2019Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in miceFull Text via DOI: 10.1186/s13041-019-0492-x Web of Science: 000482907800001
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2019Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus. GLIA. 67:1434-1448.Full Text via DOI: 10.1002/glia.23616 Web of Science: 000470958100002
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2019P1‐153: DDT EXPOSURE INCREASES LEVELS OF THE AMYLOID PRECURSOR PROTEIN, AMYLOID BETA, AND PROINFLAMMATORY FACTORS: MECHANISTIC LINKS TO ALZHEIMER'S DISEASE RISK. ALZHEIMERS & DEMENTIA. 15:p295-p295.Full Text via DOI: 10.1016/j.jalz.2019.06.708
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2019Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. CELL REPORTS. 27:3844-+.Full Text via DOI: 10.1016/j.celrep.2019.05.087 Web of Science: 000472715000013
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2019Brain region-specific regulation of histone acetylation and efflux transporters in mice. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 33.Full Text via DOI: 10.1002/jbt.22318 Web of Science: 000487281700016
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2019Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid. TOXICOLOGY. 416:15-22.Full Text via DOI: 10.1016/j.tox.2019.01.014 Web of Science: 000461262900002
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2019Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin. TOXICOLOGICAL SCIENCES. 167:249-257.Full Text via DOI: 10.1093/toxsci/kfy238 Web of Science: 000462862400022
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2018Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. TOXICOLOGY AND APPLIED PHARMACOLOGY. 359:102-107.Full Text via DOI: 10.1016/j.taap.2018.09.011 Web of Science: 000448633000011
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2018The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6. EXPERIMENTAL NEUROLOGY. 308:111-119.Full Text via DOI: 10.1016/j.expneurol.2018.07.005 Web of Science: 000442714900011
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2018RNAseq analysis of hippocampal microglia after kainic acid-induced seizuresFull Text via DOI: 10.1186/s13041-018-0376-5 Web of Science: 000435906000001
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2018The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor. JOURNAL OF NEUROINFLAMMATION. 15.Full Text via DOI: 10.1186/s12974-018-1100-1 Web of Science: 000427173900001
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2018Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease. PARKINSONS DISEASE. 2018.Full Text via DOI: 10.1155/2018/6537072 Web of Science: 000428344200001
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2017MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype. ACS CHEMICAL NEUROSCIENCE. 8:2759-2765.Full Text via DOI: 10.1021/acschemneuro.7b00287 Web of Science: 000418786100023
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2017Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1Full Text via DOI: 10.1016/j.neuropharm.2017.07.020 Web of Science: 000411775700016
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2017The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis. TOXICOLOGY AND APPLIED PHARMACOLOGY. 330:1-8.Full Text via DOI: 10.1016/j.taap.2017.06.023 Web of Science: 000407662600001
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2017Developmental pyrethroid exposure causes long-term decreases of neuronal sodium channel expression. NEUROTOXICOLOGY. 60:274-279.Full Text via DOI: 10.1016/j.neuro.2016.04.002 Web of Science: 000403133600033
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2017Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss. NEUROTOXICOLOGY. 60:99-106.Full Text via DOI: 10.1016/j.neuro.2017.03.008 Web of Science: 000403133600011
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2017Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels. TOXICOLOGICAL SCIENCES. 155:112-123.Full Text via DOI: 10.1093/toxsci/kfw187 Web of Science: 000397041300010
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2016P3‐190: Relationship between Serum Pesticide Levels and Cognitive Function in Elderly Individuals in the United States: Race/Ethnicity Differences. ALZHEIMERS & DEMENTIA. 12:p894-p894.Full Text via DOI: 10.1016/j.jalz.2016.06.2396
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2016Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. TOXICOLOGICAL SCIENCES. 151:150-159.Full Text via DOI: 10.1093/toxsci/kfw031 Web of Science: 000376662800013
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2016Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampus. NEUROTOXICOLOGY. 54:72-80.Full Text via DOI: 10.1016/j.neuro.2016.03.023 Web of Science: 000377054100008
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2016Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1378:80-86.Full Text via DOI: 10.1111/nyas.13156 Web of Science: 000394087800009
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2015Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 29:545-551.Full Text via DOI: 10.1002/jbt.21725 Web of Science: 000367688500001
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2015Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication. TOXICOLOGY AND APPLIED PHARMACOLOGY. 288:114-120.Full Text via DOI: 10.1016/j.taap.2015.07.023 Web of Science: 000362145600013
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2015Developmental Deltamethrin Exposure Causes Persistent Changes in Dopaminergic Gene Expression, Neurochemistry, and Locomotor Activity in Zebrafish. TOXICOLOGICAL SCIENCES. 146:235-243.Full Text via DOI: 10.1093/toxsci/kfv087 Web of Science: 000359630300004
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2015Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma Cells. NEUROCHEMICAL RESEARCH. 40:1372-1378.Full Text via DOI: 10.1007/s11064-015-1601-6 Web of Science: 000357509700006
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2015Ephrin-A5 regulates inter-male aggression in mice. BEHAVIOURAL BRAIN RESEARCH. 286:300-307.Full Text via DOI: 10.1016/j.bbr.2015.03.001 Web of Science: 000353599600040
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2015Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB JOURNAL. 29:1960-1972.Full Text via DOI: 10.1096/fj.14-260901 Web of Science: 000354114600030
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2015Inhibition of Sepiapterin Mediated Formation of Dihydrobiopterin and Chemical Redox Cycling by Sulfa Drugs. FASEB JOURNAL. 29.Full Text via DOI: 10.1096/fasebj.29.1_supplement.621.14
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2015Role of Calcium and Calpain in the Downregulation of Voltage-Gated Sodium Channel Expression by the Pyrethroid Pesticide Deltamethrin. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 29:129-134.Full Text via DOI: 10.1002/jbt.21676 Web of Science: 000350662600005
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2015Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin Reductase. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 352:529-540.Full Text via DOI: 10.1124/jpet.114.221572 Web of Science: 000351036400012
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2015Modulation of Microglial Process Convergence Toward Neuronal Dendrites by Extracellular Calcium. JOURNAL OF NEUROSCIENCE. 35:2417-2422.Full Text via DOI: 10.1523/JNEUROSCI.3279-14.2015 Web of Science: 000349686500010
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2015Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. PARKINSONS DISEASE. 2015.Full Text via DOI: 10.1155/2015/812532 Web of Science: 000360146800001
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2015Hippocampal ER Stress and Learning Deficits Following Repeated Pyrethroid Exposure. TOXICOLOGICAL SCIENCES. 143:220-228.Full Text via DOI: 10.1093/toxsci/kfu226 Web of Science: 000350101700023
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2014MDR1 Transporter Protects Against Paraquat-Induced Toxicity in Human and Mouse Proximal Tubule Cells. TOXICOLOGICAL SCIENCES. 141:475-483.Full Text via DOI: 10.1093/toxsci/kfu141 Web of Science: 000343045100017
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2014Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. 279:43-52.Full Text via DOI: 10.1016/j.taap.2014.04.026 Web of Science: 000338756700005
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2014Fibroblast growth factor 15 deficiency impairs liver regeneration in miceFull Text via DOI: 10.1152/ajpgi.00337.2013 Web of Science: 000336844200009
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2014Prenatal cigarette smoke exposure causes hyperactivity and aggressive behavior: Role of altered catecholamines and BDNF. EXPERIMENTAL NEUROLOGY. 254:145-152.Full Text via DOI: 10.1016/j.expneurol.2014.01.016 Web of Science: 000333321300015
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2014Elevated Serum Pesticide Levels and Risk for Alzheimer Disease. JAMA NEUROLOGY. 71:284-290.Full Text via DOI: 10.1001/jamaneurol.2013.6030 Web of Science: 000332831600005
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2013Coordinated role of voltage-gated sodium channels and the Na+/H+ exchanger in sustaining microglial activation during inflammation. TOXICOLOGY AND APPLIED PHARMACOLOGY. 273:355-364.Full Text via DOI: 10.1016/j.taap.2013.09.011 Web of Science: 000328099500012
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2013The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism. EXPERIMENTAL NEUROLOGY. 250:376-383.Full Text via DOI: 10.1016/j.expneurol.2013.10.014 Web of Science: 000328305600040
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2013Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 110:19561-19566.Full Text via DOI: 10.1073/pnas.1318830110 Web of Science: 000327390400093
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2013Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: Role of dopamine handling in neurotoxicity. EXPERIMENTAL NEUROLOGY. 241:138-147.Full Text via DOI: 10.1016/j.expneurol.2012.12.013 Web of Science: 000315315800017
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2013Acute Effects of Pyrethroids on Serotonin Release in the Striatum of Awake Rats: An In Vivo Microdialysis Study. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 27:150-156.Full Text via DOI: 10.1002/jbt.21450 Web of Science: 000315188700006
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2013Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 27:165-171.Full Text via DOI: 10.1002/jbt.21477 Web of Science: 000315188700008
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2013Inhibition of Human MDR1 and BCRP Transporter ATPase Activity by Organochlorine and Pyrethroid Insecticides. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 27:157-164.Full Text via DOI: 10.1002/jbt.21458 Web of Science: 000315188700007
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2013Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver. TOXICOLOGY AND APPLIED PHARMACOLOGY. 266:260-266.Full Text via DOI: 10.1016/j.taap.2012.11.012 Web of Science: 000313758200010
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2013Ephrin-A5 deficiency alters sensorimotor and monoaminergic development. BEHAVIOURAL BRAIN RESEARCH. 236:139-147.Full Text via DOI: 10.1016/j.bbr.2012.08.032 Web of Science: 000310929400018
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2012Inflammatory Regulation of ATP Binding Cassette Efflux Transporter Expression and Function in Microglia. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 343:650-660.Full Text via DOI: 10.1124/jpet.112.196543 Web of Science: 000311099300012
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2012Polybrominated diphenyl ethers enhance the production of proinflammatory cytokines by the placenta. PLACENTA. 33:745-749.Full Text via DOI: 10.1016/j.placenta.2012.06.005 Web of Science: 000308896300013
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2012P3‐128: A DDT metabolite is elevated in the serum of Alzheimer's disease patients. ALZHEIMERS & DEMENTIA. 8:p496-p496.Full Text via DOI: 10.1016/j.jalz.2012.05.1348
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2012Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease. EXPERIMENTAL NEUROLOGY. 234:482-487.Full Text via DOI: 10.1016/j.expneurol.2012.01.022 Web of Science: 000301994900025
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2011β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease. NEUROTOXICOLOGY. 32:640-645.Full Text via DOI: 10.1016/j.neuro.2011.04.002 Web of Science: 000296671800017
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2011Mechanism of Pyrethroid Pesticide-Induced Apoptosis: Role of Calpain and the ER Stress Pathway. TOXICOLOGICAL SCIENCES. 122:512-525.Full Text via DOI: 10.1093/toxsci/kfr111 Web of Science: 000293914500026
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2011Fused-core silica column ultra-performance liquid chromatography-ion trap tandem mass spectrometry for determination of global DNA methylation status. ANALYTICAL BIOCHEMISTRY. 409:138-143.Full Text via DOI: 10.1016/j.ab.2010.10.012 Web of Science: 000286126500019
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2010Developmental Neurotoxicity of Pyrethroid Insecticides in Zebrafish Embryos. TOXICOLOGICAL SCIENCES. 113:177-186.Full Text via DOI: 10.1093/toxsci/kfp258 Web of Science: 000272935700017
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2009Elevated Serum Pesticide Levels and Risk of Parkinson Disease. ARCHIVES OF NEUROLOGY. 66:870-875.Full Text via DOI: 10.1001/archneurol.2009.89 Web of Science: 000268189200009
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2009Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain. NEUROTOXICOLOGY. 30:274-280.Full Text via DOI: 10.1016/j.neuro.2008.12.015 Web of Science: 000264912700014
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2009Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brain. EXPERIMENTAL NEUROLOGY. 215:358-367.Full Text via DOI: 10.1016/j.expneurol.2008.11.003 Web of Science: 000262890900019
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2008Treadmill Gait Analysis Does Not Detect Motor Deficits in Animal Models of Parkinson's Disease or Amyotrophic Lateral Sclerosis. JOURNAL OF MOTOR BEHAVIOR. 40:568-577.Full Text via DOI: 10.3200/JMBR.40.6.568-577 Web of Science: 000260724000010
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2008Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner. NEUROTOXICOLOGY. 29:855-863.Full Text via DOI: 10.1016/j.neuro.2008.05.007 Web of Science: 000260516100013
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2008Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis. JOURNAL OF NEUROCHEMISTRY. 106:2205-2217.Full Text via DOI: 10.1111/j.1471-4159.2008.05568.x Web of Science: 000258360000019
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2008PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicityFull Text via DOI: 10.1016/j.npep.2008.04.003 Web of Science: 000259470200005
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2008Disruption of dopamine transport by DDT and its metabolites. NEUROTOXICOLOGY. 29:682-690.Full Text via DOI: 10.1016/j.neuro.2008.04.010 Web of Science: 000257819500016
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2008Na+/H+ exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions. JOURNAL OF NEUROCHEMISTRY. 106:231-243.Full Text via DOI: 10.1111/j.1471-4159.2008.05355.x Web of Science: 000256718600020
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2007Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. JOURNAL OF NEUROSCIENCE. 27:8138-8148.Full Text via DOI: 10.1523/JNEUROSCI.0319-07.2007 Web of Science: 000248484800026
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2007Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system. EXPERIMENTAL NEUROLOGY. 204:619-630.Full Text via DOI: 10.1016/j.expneurol.2006.12.020 Web of Science: 000245682900013
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2007Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease. JOURNAL OF NEUROCHEMISTRY. 100:1469-1479.Full Text via DOI: 10.1111/j.1471-4159.2006.04333.x Web of Science: 000244720700004
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2007Divergent mechanisms of paraquat, MPP+, and rotenone toxicity:: Oxidation of thioredoxin and caspase-3 activation. TOXICOLOGICAL SCIENCES. 95:163-171.Full Text via DOI: 10.1093/toxsci/kfl125 Web of Science: 000243072300016
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2007Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). TOXICOLOGICAL SCIENCES. 95:196-204.Full Text via DOI: 10.1093/toxsci/kfl133 Web of Science: 000243072300020
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2006Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease. FASEB JOURNAL. 20:1695-+.Full Text via DOI: 10.1096/fj.06-5864fje Web of Science: 000240266600018
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2006Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to Parkinson's disease-associated dopamine toxicity. TOXICOLOGICAL SCIENCES. 92:490-499.Full Text via DOI: 10.1093/toxsci/kfl018 Web of Science: 000238907300016
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2006Pyrethroid pesticide-induced alterations in dopamine transporter function. TOXICOLOGY AND APPLIED PHARMACOLOGY. 211:188-197.Full Text via DOI: 10.1016/j.taap.2005.06.003 Web of Science: 000236532900002
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2005Paraquat neurotoxicity is distinct from that of MPTP and rotenone. TOXICOLOGICAL SCIENCES. 88:193-201.Full Text via DOI: 10.1093/toxsci/kfi304 Web of Science: 000232428300022
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2005Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum. NEUROTOXICOLOGY. 26:721-728.Full Text via DOI: 10.1016/j.neuro.2004.09.003 Web of Science: 000231689400022
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2005Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats. TOXICOLOGICAL SCIENCES. 84:352-359.Full Text via DOI: 10.1093/toxsci/kfi081 Web of Science: 000227973900018
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2004Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels. TOXICOLOGY LETTERS. 148:29-40.Full Text via DOI: 10.1016/j.toxlet.2003.12.006 Web of Science: 000220283700004
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2004Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats. TOXICOLOGICAL SCIENCES. 77:83-90.Full Text via DOI: 10.1093/toxsci/kfh014 Web of Science: 000187988800011
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2003Mechanism of toxicity in rotenone models of Parkinson's disease. JOURNAL OF NEUROSCIENCE. 23:10756-10764.Full Text via DOI: 10.1523/jneurosci.23-34-10756.2003 Web of Science: 000186902500002
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2003Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistry. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 66:275-289.Full Text via DOI: 10.1080/15287390306369 Web of Science: 000180896800005
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2002Effects of PCB exposure on the toxic impact of organophosphorus insecticides. TOXICOLOGICAL SCIENCES. 67:311-321.Full Text via DOI: 10.1093/toxsci/67.2.311 Web of Science: 000175852800019
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2001Analysis of the additivity of in vitro inhibition of cholinesterase by mixtures of chlorpyrifos-oxon and azinphos-methyl-oxon. TOXICOLOGY AND APPLIED PHARMACOLOGY. 172:128-139.Full Text via DOI: 10.1006/taap.2001.9140 Web of Science: 000168452500006
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2001Effects of repeated oral postnatal exposure to chlorpyrifos on open-field behavior in juvenile rats. TOXICOLOGICAL SCIENCES. 59:260-267.Full Text via DOI: 10.1093/toxsci/59.2.260 Web of Science: 000166638300010
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Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD. NEUROTOXICOLOGY AND TERATOLOGY. 52:162-169.Full Text via DOI: 10.1016/j.ntt.2015.06.003 Web of Science: 000367108400007
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Book Chapter
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2020Regulation of tyrosine hydroxylase: Relevance to Parkinson’s disease. 51-66.Full Text via DOI: 10.1016/B978-0-12-815950-7.00004-7
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2019Chapter 30 Pharmacoepigenetics and Pharmacoepigenomics of Valproate in Neurodegenerative Disease. 801-816.Full Text via DOI: 10.1016/b978-0-12-813939-4.00030-9
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2019Pharmacoepigenetics and Pharmacoepigenomics of Valproate in Neurodegenerative Disease. 801-816.Full Text via DOI: 10.1016/B978-0-12-813939-4.00030-9 Web of Science: 000560031400031
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20186.04 Selective Vulnerability in the Nervous System☆. 41-49.Full Text via DOI: 10.1016/b978-0-08-100601-6.02188-8
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2018Selective Vulnerability in the Nervous System. 41-49.Full Text via DOI: 10.1016/B978-0-08-100601-6.02188-8
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2017Neuroprotective Properties of Dietary Polyphenols in Parkinson's Disease. 243-263.Full Text via DOI: 10.1002/9781119155195.ch11
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2017Selective Vulnerability in the Nervous SystemFull Text via DOI: 10.1016/b978-0-12-801238-3.02188-7
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2015Chapter 13 Parkinson’s Disease Mechanisms, Models, and Biological Plausibility. 267-288.Full Text via DOI: 10.1016/b978-0-12-800228-5.00013-3
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2015Parkinson's Disease: Mechanisms, Models, and Biological Plausibility. 267-288.Full Text via DOI: 10.1016/B978-0-12-800228-5.00013-3 Web of Science: 000416954000015
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2010Genetic and Environmental Factors in Attention-Deficit Hyperactivity Disorder. 257-274.Full Text via DOI: 10.1002/9780470917060.ch14
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201013.03 Selective Vulnerability in the Nervous System*. 29-38.Full Text via DOI: 10.1016/b978-0-08-046884-6.01303-8
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2010Selective Vulnerability in the Nervous System. 29-38.Web of Science: 000333465100003
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Conference
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2018Retinal amyloid pathology requires CD36 receptors.. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.Web of Science: 000442932801246
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2018
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2017Translational Studies on the Role of Developmental Pyrethroid Exposure in ADHD: From Cells to Zebrafish to Mice to Humans and Back Again. NEUROTOXICOLOGY AND TERATOLOGY. 145-145.Web of Science: 000403512700024
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2017A Novel Neuroprotective Effect of Osteoactivin in Parkinson's Disease. FASEB JOURNAL.Web of Science: 000405986501129
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2017Histone Modification is a Novel Epigenetic Mechanism to Up-Regulate Human Blood-Brain Barrier Transporters. FASEB JOURNAL.Web of Science: 000405986501536
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2015Hepatic but not Intestinal Specific FXR Deficiency Led to Accelerated Non-alcoholic Steatohepatitis Development. HEPATOLOGY. 662A-662A.Web of Science: 000368375402243
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2015Role of fibroblast growth factor 15 in the development of high fat diet induced NASH. HEPATOLOGY. 669A-669A.Web of Science: 000368375402258
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2013Fibroblast Growth Factor 15 is Critical for Liver Regeneration after Partial Hepatectomy in Mice. HEPATOLOGY. 287A-288A.Web of Science: 000330252201159
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2012Reduced ABC efflux transporter function in activated microglia: Implications in neurodegeneration. FASEB JOURNAL.Web of Science: 000310711301279
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2011Prenatal Cigarette Smoke Exposure Causes Gender-Specific Neurobehavioral Alterations Reminiscent of ADHD with Increased Aggression. NEUROTOXICOLOGY AND TERATOLOGY. 501-501.Full Text via DOI: 10.1016/j.ntt.2011.05.035 Web of Science: 000294527900032
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2010Using the zebrafish (Danio rerio) model to investigate changes in gene expression and behavior following developmental exposure to pyrethroid pesticides. NEUROTOXICOLOGY AND TERATOLOGY. 502-503.Full Text via DOI: 10.1016/j.ntt.2010.04.025 Web of Science: 000279528000033
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2009Down-regulation of DNA methyltransferase expression is associated with increased dopaminergic gene expression following developmental pyrethroid exposure. NEUROTOXICOLOGY AND TERATOLOGY. 242-242.Full Text via DOI: 10.1016/j.ntt.2009.04.026 Web of Science: 000267253900029
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2009Exposure to pyrethroid insecticides alters expression of genes important for dopaminergic neuronal development. NEUROTOXICOLOGY AND TERATOLOGY. 241-241.Full Text via DOI: 10.1016/j.ntt.2009.04.022 Web of Science: 000267253900025
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2009Exposure to Pyrethroid Insecticides Alters Expression of Genes Important for Dopaminergic Neuronal Development. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY. 405-405.Web of Science: 000266695900055
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2008Developmental pesticide exposure: A new risk factor for ADHD?. NEUROTOXICOLOGY AND TERATOLOGY. 251-251.Full Text via DOI: 10.1016/j.ntt.2008.03.030 Web of Science: 000257303100038
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2006Developmental pesticide exposure reproduces features of attention-deficit hyperactivity disorder.. NEUROTOXICOLOGY. 1161-1161.Web of Science: 000243211300064
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2006Elevated levels of dieldrin are associated with Parkinson's disease. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 647-647.Web of Science: 000207781604578
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2006Developmental pesticide exposure alters the dopaminergic system and increases MPTP toxicity.. NEUROTOXICOLOGY. 904-904.Web of Science: 000240408800095
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2005Activation of PKC and down-regulation of the dopamine transporter following in vivo exposure to polychlorinated biphenyls. FASEB JOURNAL. A1080-A1080.Web of Science: 000227610900502
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2004Dopamine transporter and vesicular monoamine transporter levels are increased by perinatal heptachlor exposure.. NEUROTOXICOLOGY. 727-727.Web of Science: 000222121900178
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2004Perinatal exposure to deltamethrin alters dopaminergic neurochemistry in the developing mouse brain.. NEUROTOXICOLOGY. 714-715.Web of Science: 000222121900145
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2004Screening of pesticides that inhibit complex I: Relevance to Parkinson's disease.. NEUROTOXICOLOGY. 704-704.Web of Science: 000222121900119
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2003Effect of pyrethroids on dopamine uptake in SK-N-MC cells expressing the dopamine transporter. FASEB JOURNAL. A236-A236.Web of Science: 000181733101135
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2003Effects of repeated developmental exposure to chlorpyifos and methyl parathion on choline acetyltransferase and muscarinic receptors in rats.. TOXICOLOGICAL SCIENCES. 127-127.Web of Science: 000181518500622
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2003Effects of repeated developmental exposure to chlorpyrifos on presynaptic neurochemical components of the cholinergic system. NEUROTOXICOLOGY. 305-305.Web of Science: 000181511000060
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2003Polychlorinated biphenyls inhibit dopamine uptake in human neuroblastoma cells stably expressing the human dopamine transporter. NEUROTOXICOLOGY. 304-305.Web of Science: 000181511000059
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2003Polychlorinated biphenyls inhibit dopamine uptake in human neuroblastoma cells stably expressing the human dopamine transporter.. TOXICOLOGICAL SCIENCES. 265-265.Web of Science: 000181518501295
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Editorial Material
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2021Neurotoxicology. CHEMICAL RESEARCH IN TOXICOLOGY. 1197.Full Text via DOI: 10.1021/acs.chemrestox.1c00147
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Letter
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2014Testosterone as the Missing Link Between Pesticides, Alzheimer Disease, and Parkinson Disease Reply. JAMA NEUROLOGY. 1190-1190.Full Text via DOI: 10.1001/jamaneurol.2014.1814 Web of Science: 000341977300020
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2014Alzheimer Disease Risk Factors. JAMA NEUROLOGY. 1051-1051.Full Text via DOI: 10.1001/jamaneurol.2014.1525 Web of Science: 000340481800019
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2014Elevated Serum DDE and Risk for Alzheimer Disease Reply. JAMA NEUROLOGY. 1056-1056.Full Text via DOI: 10.1001/jamaneurol.2014.1548 Web of Science: 000340481800026
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Other Scholarly Work
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2023Methods for shipping live primary cortical and hippocampal neuron cultures from postnatal mice.. 100069.Full Text via DOI: 10.1016/j.crneur.2022.100069
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2022Erratum: Polychlorinated Biphenyl-Induced Reduction of Dopamine Transporter Expression as a Precursor to Parkinson's Disease-Associated Dopamine Toxicity (Toxicological Sciences (2006) 92:2 (490–499) DOI: 10.1093/toxsci/kfl018). TOXICOLOGICAL SCIENCES. 175.Full Text via DOI: 10.1093/toxsci/kfab155
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2020Call for Papers for the Special Issue on Neurotoxicology. CHEMICAL RESEARCH IN TOXICOLOGY. 2009-2009.Full Text via DOI: 10.1021/acs.chemrestox.0c00295 Web of Science: 000620022600001
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2020L-Plastin, a Novel Regulator of Microglial Activation in Parkinsons disease. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.09750 Web of Science: 000546107900342
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2019Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration. FASEB JOURNAL.Web of Science: 000496555200202
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2019"Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin" (vol 167, pg 249, 2019). TOXICOLOGICAL SCIENCES. 281-281.Full Text via DOI: 10.1093/toxsci/kfy305 Web of Science: 000462865100026
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2017"Ephrin-A5 regulates inter-male aggression in mice (vol 286, pg 300, 2015). BEHAVIOURAL BRAIN RESEARCH. 223-223.Full Text via DOI: 10.1016/j.bbr.2017.08.019 Web of Science: 000412034100028
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2014Repeated deltamethrin exposure causes cognitive deficits in mice: Role of ER stress and Impaired Neurogenesis. NEUROTOXICOLOGY AND TERATOLOGY. 89-89.Full Text via DOI: 10.1016/j.ntt.2014.04.044 Web of Science: 000338621800051
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2013Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression (vol 27, pg 165, 2013). JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 251-252.Full Text via DOI: 10.1002/jbt.21480 Web of Science: 000317134500004
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2011Unifying mechanisms of neurological disorders - Scientific, translational and clinical implications: Overview and theme of the 26th International Neurotoxicology Conference. NEUROTOXICOLOGY. 499-508.Full Text via DOI: 10.1016/j.neuro.2011.08.005 Web of Science: 000296671800001
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Preprint
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Review
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2022Glyphosate and neurological outcomes: A systematic literature review of animal studies. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS. 162-209.Full Text via DOI: 10.1080/10937404.2022.2083739 Web of Science: 000808465500001
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2021Microglia in Aging and Alzheimer's Disease: A Comparative Species ReviewFull Text via DOI: 10.3390/cells10051138 Web of Science: 000654732600001
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2020Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. 459-480.Full Text via DOI: 10.1124/dmd.119.089953 Web of Science: 000551340100006
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2019Neurotoxicity of pesticides. 343-362.Full Text via DOI: 10.1007/s00401-019-02033-9 Web of Science: 000480599000002
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2019Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine. PHARMACOLOGY & THERAPEUTICS. 173-187.Full Text via DOI: 10.1016/j.pharmthera.2019.03.005 Web of Science: 000474321600012
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2018Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease. MOLECULAR NEUROBIOLOGY. 5167-5176.Full Text via DOI: 10.1007/s12035-017-0707-z Web of Science: 000431991500050
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2018Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration. 432-443.Full Text via DOI: 10.1016/j.bbadis.2017.11.004 Web of Science: 000424074300010
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2013Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson's Disease. NEURAL PLASTICITY.Full Text via DOI: 10.1155/2013/587418 Web of Science: 000326757300001
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Research
principal investigator on
- Microglial Hv1 Proton Channel as a Mediator of Environmentally-Induced Neuroinflammation and Neurodegeneration awarded by Environmental Health Sciences 2022 - 2026
- Association of the in Utero Exposome with Life-Course Cognition and Prodromal Alzheimer's Disease in Midlife awarded by Neurological Disorders and Stroke 2022 - 2025
- Health Disparities in Alzheimers and Related Diseases awarded by National Institute on Aging 2020 - 2025
- Gene-environment interactions between the APOE genotype and Mn in neurodegenerative disease awarded by Bristol-Myers Squibb 2022 - 2024
- Advanced Development of Drugs to Mitigate Parathion Intoxication awarded by Neurological Disorders and Stroke 2022 - 2023
- Increasing nigral tyrosine hydroxylase expression, a mechanism of exercise mediated-recovery: Evaluation in toxin and rat Parkinson's disease genetic models awarded by U.S. Department of Defense 2019 - 2023
- Mechanism of Gene Environment Interactions in Alzheimer's Disease awarded by Environmental Health Sciences 2018 - 2023
- Advanced Development of Drugs to Mitigate Parathion Intoxication awarded by Neurological Disorders and Stroke 2021 - 2022
- Advanced Development of Drugs to Mitigate Parathion Intoxication awarded by Neurological Disorders and Stroke 2018 - 2021
- Neuroinflammation and abnormal behavior following combined chemical exposures and bacterial infection awarded by U.S. Department of Veterans Affairs 2019 - 2020
- Gene-Environment Interactions in Neurodegeneration: Role of Efflux Transporters awarded by Environmental Health Sciences 2018 - 2020
- Translational Studies on the Role of Pesticides in Cognitive Aging and AD awarded by Environmental Health Sciences 2018 - 2020
- Neuroinflammation and abnormal behavior following combined chemical exposures and bacterial infection awarded by U.S. Department of Veterans Affairs 2019 - 2020
- Developing Drugs to Mitigate Parathion Intoxication awarded by Neurological Disorders and Stroke 2018 - 2019
- Farnesoid X Receptor as a Target to Reduce Neuroinflammation awarded by Michael J. Fox Foundation for Parkinson 2018 - 2019
co-principal investigator on
subproject principal investigator on
- COR: Training in Environmental Neuroscience awarded by Environmental Health Sciences 2023 - 2028
- Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT) awarded by National Institute of Mental Health 2023 - 2026
investigator on
- Pesticide Exposure and Adult Neurogenesis: Role of ER Stress awarded by Environmental Health Sciences 2018 - 2024
Identifiers
ORCID iD
- https://orcid.org/0000-0001-6521-610X (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in